Bioactive Small Molecules
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Filtered Search Results
Abcam AMD3100 octahydrochloride, C x CR4 antagonist, 1MG
MW 794.5 Da, Purity >99%. Plerixafor (hydrochloride) is a macrocyclic compound that acts as an irreversible antagonist against the binding of CXCR4 with its ligand, SDF-1 (CXCL12). It suppresses infection by HIV with an IC₅₀ value of 1-10 ng/ml with selectivity toward CXCR4-tropic virus. Plerixafor mobilizes hematopoietic stem and progenitor cells for transplant better than G-CSF alone. It also increases T-cell trafficking in the blood and spleen as well as the central nervous system. Plerixafor regulates the growth of primary and metastic breast cancer cells and inhibits dissemination of ovarian carcinoma cells.
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Selleck Chemical LLC Xanomeline E4714-1G
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Xanomeline(LY-246708) is a selective agonist of muscarinic type 1(M(1) receptor and muscarinic type 4 receptor(M(4) It increases neuronal excitability and inhibits behaviors induced by D-amphetamine and (-)-apomorphine
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Selleck Chemical LLC Phenol Red E7437-1G
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Phenol red is a pH indicator dye commonly used in cell culture media where it changes color from yellow to red based on pH levels It also participates in redox reactions particularly in the presence of enzymes like myeloperoxidase influencing cellular oxidative states without directly causing significant toxicity
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Selleck Chemical LLC Cyclizine hydrochloride E4905-100MG
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Cyclizine hydrochloride is an antagonist of the H1 histamine receptor used for the treatment and prevention of vertigo and motion sickness It also exhibits antihistaminic properties
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Selleck Chemical LLC BIO-2007817 E5771-1G
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BIO-2007817 is a tetrahydropyrazolo-pyrazine and a positive allosteric modulator(PAM) that can act as a molecular glue to enhance the ability of pUb to activate Parkin with an EC50 of 150 nM It can be used in research design of activators as therapeutics for Parkinson s disease
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Medchemexpress LLC Somatostatin-28 1-1 | 1MG
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Somatostatin-28 1-1 | 1MG
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Sigma Aldrich Fine Chemicals Biosciences S0859 >=98% (HPLC) | 1019331-10-2 | 25MG
S0859 >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 530.04 | 1019331-10-2 | 25MG
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Enzo Life Sciences MnTBAP chloride (10mg)
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Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Inhibits neuronal apoptosis. Purity: ≥95% (TLC). Appearance: Black crystalline powder. Solubility: Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed. Long Term Storage: -20°C.
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Selleck Chemical LLC Orcinol S9329-25MG
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Orcinol (5-Methylresorcinol 3 5-ToluenediolOrcin 5-Methyl-1 3-benzenediol 3 5-Dihydroxytoluene) occurs in many species of lichens including Roccella tinctoria and Lecanora exhibits antimutagenic antioxidant antibacterial radical-scavenging effects
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Selleck Chemical LLC Lanifibranor S8770-10MM/1ML
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Lanifibranor (IVA-337) is a moderately potent and well balanced pan PPAR agonist with EC50 values of 1537 nM 866 nM and 206 nM for hPPAR hPPAR and hPPAR respectively
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Selleck Chemical LLC TH34 S8773-5MG
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TH34 is a HDAC inhibitor that shows pronounced selectivity for HDACs 6 8 and 10 over HDACs 1 2 and 3 In a NanoBRET assay TH34 strongly binds HDAC6 8 and 10 with low-micromolar IC50 concentrations (HDAC6 4 6 M HDAC8 1 9 M HDAC10 7 7 M)
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Selleck Chemical LLC Ac-FLTD-CMK S9817-25MG
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Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1 -4 -5 and -11 in vitro Ac-FLTD-CMK is effective against caspases-1 caspases-4 and caspases-5 with IC50 of 46 7 nM 1 49 M and 329 nM respectively
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Selleck Chemical LLC Deucravacitinib S8879-25MG
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Deucravacitinib (BMS-986165) is a highly potent and selective allosteric inhibitor of Tyk2 with a Ki value of 0 02 nM for binding to the Tyk2 pseudokinase domain It is highly selective against a panel of 265 kinases and pseudokinases
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Selleck Chemical LLC Gramicidin E2970-100MG
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Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) is an antimicrobial peptide that destroys gram-positive bacteria It inhibits the growth of bacteria by forming pores and channels in the cell wall which increase its permeability to monovalent cations
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Selleck Chemical LLC Citalopram E4953-50MG
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Citalopram is a selective serotonin reuptake inhibitor (SSRI) that selectively inhibits the 5-HT transporter blocks the reuptake of 5-HT in the presynaptic membrane prolongs and increases the effects of 5-HT and enhances serotonin neurotransmission by potently and selectively inhibiting serotonin reuptake (SSRI)
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