Bioactive Small Molecules
Cayman Chemical Roquinimex, Purity: ≥98%, CAS: 84088-42-6, 10 mg
An immunomodulator with diverse biological activities; increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis at 80 mg/kg; induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic GVHD; decreases colonic MPO activity and mucosal damage in a mouse model of DSS-induced colitis at 300 mg/kg; decreases tumor weight and tumor blood flow in a VHL type 2a paraganglioma mouse xenograft model
Cayman Chemical SB-674042, Purity: ≥98%, CAS: 483313-22-0, 1 mg
A potent and selective non-peptide OX1R antagonist (Kd = 5.03 and 3.76 nM in whole cell binding and membrane-based assays, respectively); >100-fold selective for OX1 over OX2 in calcium mobilization; no significant affinity for serotonergic, dopaminergic, adrenergic, or purinergic receptors
Medchemexpress LLC HY-107777 5mg Medchemexpress, LLY-283 CAS:2040291-27-6 Purity:>98%
Medchemexpress, HY-107777 5mg LLY-283 CAS:2040291-27-6 LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 ( PRMT5 ) inhibitor, with an IC 50 of 22 nM and a K d of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Triciribine | 35943-35-2 | C13H16N6O4 | 100 MG
Triciribine is a nucleoside analog and purine analog that functions as a DNA synthesis inhibitor. It also inhibits Akt and HIV-1/2 with specific IC50 values. This compound selectively inhibits the phosphorylation and activation of all three Akt isoforms, effectively inhibiting Akt catalytic activity in PC-3 cells at 10 μM.
- Inhibits DNA synthesis
- Inhibits Akt phosphorylation and activation
- Inhibits HIV-1/2
- Effective at inhibiting catalytic activity of Akt in PC-3 cells
Medchemexpress LLC HY-N2438 5mg Medchemexpress, Methylophiopogonanone B CAS:74805-91-7 Purity:>98%
Medchemexpress, HY-N2438 5mg Methylophiopogonanone B CAS:74805-91-7 Methylophiopogonanone B, homoisoflavonoid, is extracted from the root of Ophiopogon japonicas, shows high antioxidant ability. Methylophiopogonanone B increases GTP-Rho and acts via the Rho signaling pathway, inducing cell morphological change via actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 1160852-22-1 | Medchem Express | S130 | 5mg | 485251326 | HY-112818 | 387.483 | C24H25N3O2
ChemScene | 6-(3-Chloropropoxy)-2-(4-(3-chloropropoxy)phenyl)benzo[d]oxazole | 100mg | 726025441 | CS-0530143 | 1219925-75-3 | 380.270 | C19H19Cl2NO3
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Cayman Chemical Aloin, Purity: ≥95%, CAS: 452311-56-7, 500 mg
An anthraquinone with diverse biological activities; reduces IL-6 and TNF-a expression as well as NO production and COX-2 and iNOS expression in LPS-stimulated RAW 264.7 from 100-400 mM; inhibits LPS-induced p65 acetylation, nuclear translocation of NF-kB, and apoptosis in RAW 264.7 cells; reduces motility of T. congolense in vitro and reduces the number of parasites in T. congolense-infected mice at 400 mg/kg; reduces activity of GPX, GST, and GR, the level of colonic MDA, and the number of aberrant crypt foci and mucin-depleted foci in a rat model of 1,2-dimethylhydrazine-induced colon cancer
Cayman Chemical L-006,235, Purity: ≥98%, CAS: 294623-49-7, 25 mg
An orally bioavailable reversible inhibitor of cathepsin K (Ki(app) = 0.2 nM); selective for cathepsin K over cathepsins B, -L, and -S (Ki(app) = 1, 6, and 47 µM, respectively); inhibits degradation of bovine bone by isolated rabbit osteoclasts (IC50 = 5 nM); reduces loss of lumbar vertebral bone mineral density by 13.3% in ovariectomized rabbits at 10 mg/kg for 27 days; increases weight bearing, indicating analgesia, in a rat model of osteoarthritis pain at 100 mg/kg
Medchemexpress LLC Mrt67307 | 1190378-57-4 | 99.6% | 100 MG
MRT67307 is a dual inhibitor of IKKε and TBK-1, with IC50s of 160 nM and 19 nM respectively. It also inhibits ULK1 and ULK2, and blocks autophagy in cells.
- Inhibits IKKε with an IC50 of 160 nM
- Inhibits TBK-1 with an IC50 of 19 nM
- Inhibits ULK1 with an IC50 of 45 nM
- Inhibits ULK2 with an IC50 of 38 nM
- Blocks autophagy in cells
Medchemexpress LLC HY-N0898A 5mg Medchemexpress, (-)-Catechin CAS:18829-70-4 Purity:>98%
Medchemexpress, HY-N0898A 5mg (-)-Catechin CAS:18829-70-4 (-)-Catechin, isolated from green tea, is an isomer of Catechin having a trans 2S,3R configuration at the chiral center. Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC LDN-209929 dihydrochloride | 1784281-97-5 | 98.3% | 405.77 | 100 MG
LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with 180-fold selectivity verses DYRK2 (IC50=9.9 μM). It is an optimized analogue of LDN-192960. This compound targets haspin kinase, a serine/threonine kinase crucial in mitosis, and also inhibits DYRKs, a family of kinases involved in various cellular processes.
- Potent and selective haspin kinase inhibitor
- IC50 of 55 nM for haspin kinase
- 180-fold selectivity versus DYRK2
- IC50 of 9.9 μM for DYRK2
- Optimized analogue of LDN-192960
- Suitable for research in metabolic or endocrine disease, cancer, lipid metabolism, and obesity
- Targets protein tyrosine kinase/RTK and haspin kinase pathways
Cayman Chemical Acridine Orange 10-nonyl (bromide), Purity: ≥90%, CAS: 75168-11-5, 5 mg
A mitochondrial dye; incorporates into the cardiolipin-rich inner mitochondrial membrane; selectively binds to cardiolipin-containing liposomes over phosphatidylserine- and phosphatidylinositol-containing liposomes in vitro (Kas = 0.002, 7,000, and 7,000 mM, respectively); binding dependent on mitochondrial membrane potential; ex/em = 490/510 nm, respectively; has been used to quantify cardiolipin content and mitochondrial mass in isolated mitochondria and cellular systems
Medchemexpress LLC Astringin | 29884-49-9 | 1 ML
Astringin is an orally active natural flavonoid compound. It inhibits the production of oxidative stress and inflammatory factors. This compound has multiple activities, including anti-oxidation, anti-inflammation, and anti-apoptosis, and is also an inhibitor of ferroptosis. Astringin can be used in the research of diseases such as acute lung injury.
- Inhibits oxidative stress and inflammatory factors
- Exhibits anti-oxidation, anti-inflammation, and anti-apoptosis activities
- Functions as an inhibitor of ferroptosis
- Suitable for research on diseases like acute lung injury
Selleck Chemical LLC Bentamapimod S8867-2MG
Bentamapimod (AS602801) is a novel orally active JNK inhibitor with IC50 values of 80 nM 90 nM and 230 nM for JNK1 JNK2 and JNK3 respectively
Cayman Chemical Avacopan, Purity: ≥95%, CAS: 1346623-17-3, 10 mg
A C5a1 receptor antagonist (IC50 = 0.1 nM); selective for C5a1 over the C5a2 receptor and CMKLR2 (IC50s = >10,000 nM for both), as well as the C3a receptor, CMKLR1, and FPR1 (IC50s = >10,000 nM for all), and over panels of 18 chemokine receptors (IC50s = ≥6,700 nM for all), 54 other receptors at 10 µM, and five CYP isoforms (IC50s = >10,000 nM for all); reduces the migration of isolated cynomolgus monkey neutrophils at 50 nM; reduces C5a-induced increases in CD11b levels on neutrophils in isolated whole blood from human C5AR1 knock-in mice at 10 and 100 nM or at 0.075 and 0.15 mg/kg